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The SRRE identified a broader pool of sRNAs from blood samples compared with the study by the Federal Reserve Bank of Minneapolis. With a larger pool, the number of sRNA species identified is much larger, and this would explain the lower yield of shorter ncRNA species identified (Figure 2).

Blood collection from COVID-19 patients are very different than normal blood collection. The differences in RNA size, structure, and template, and the changes to blood cells, may affect the results. For example, it has been reported that in cancer patients, myeloid cells, including NK cells, have increased abundance of TFRD1 following chemotherapy and that TFRD1 represses tumor-suppressing miRNAs [112]. A recent study of blood cells of cancer patients showed that myeloid cells were the most highly expressed cells in the blood and that the top drivers to cancer are immune cells [113]. Populations enriched with activated T cells (T helper) have been defined, and evidence suggests that the activated T lymphocytes might be produced by activated monocytes and macrophages [114].

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